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清华大学学报(自然科学版)  2022, Vol. 62 Issue (10): 1730-1738    DOI: 10.16511/j.cnki.qhdxxb.2021.26.030
  生物医学 本期目录 | 过刊浏览 | 高级检索 |
基于机器学习和瞳孔响应的简易高性能自闭症分类模型
刘强墨, 何旭, 周佰顺, 吴昊霖, 张弛, 秦羽, 沈晓梅, 高小榕
清华大学 生物医学工程系, 北京 100084
Simple and high performance classification model for autism based on machine learning and pupillary response
LIU Qiangmo, HE Xu, ZHOU Baishun, WU Haolin, ZHANG Chi, QIN Yu, SHEN Xiaomei, GAO Xiaorong
Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China
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摘要 自闭症(autism spectrum disorder, ASD)的早期诊断对自闭症的康复至关重要。近年来,利用机器学习和眼动追踪技术对儿童进行早期自闭症诊断已成为自闭症领域的研究热点。该文在前人工作的基础上,提出了一种基于相对瞳孔响应的眼动数据预处理和瞳孔响应特征提取方法,并使用朴素Bayes算法构建了自闭症分类模型。在现有3~6岁的25名ASD儿童和50名典型发育(typical development, TD)儿童的眼动数据集Autism Detection Dataset上进行了验证,发现了自闭症儿童异常的瞳孔响应。实验结果表明:该文提出的方法在深入挖掘瞳孔特征并仅使用瞳孔特征建模的同时,实现了90.67%的平均分类准确率与92.24%的平均AUC值,优于前人同时使用瞳孔特征、注视行为特征来建模实现的82.2%的平均准确率的结果和同时使用注视行为特征、运动学特征来建模实现的78%的平均准确率的结果,兼具简易和高性能的优点。这不仅证明了该方法的有效性,还提高了基于机器学习和眼动追踪的这类自闭症早期辅助诊断系统真正应用到临床的可行性。
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刘强墨
何旭
周佰顺
吴昊霖
张弛
秦羽
沈晓梅
高小榕
关键词 自闭症机器学习瞳孔响应分类模型    
Abstract:Early diagnosis of autism spectrum disorder (ASD) is very important for improving autism treatment.Recent studies have investigated early diagnosis of children with ASD using machine learning and eye tracking.This paper presents an eye tracking and pupillary response feature extraction method with a naive Bayes classification model for autism that was tested on the Autism Detection Dataset,a dataset of 25 children with ASD and 50 children with typical development aged 3-6 to identify abnormal pupillary responses in children with autism.The method has an average classification accuracy of 90.67% and an average AUC of 92.24% while using only the pupillary features for modeling,which is better than the 82.2% average accuracy achieved by a pupillary and gaze behavior feature model and 78% average accuracy achieved by a gaze behavior and kinematic feature model.This method is simple and accurate.The results show the effectiveness of this method and the feasibility of real clinical applications of this type for early autism diagnosis based on machine learning and eye tracking.
Key wordsautism    machine learning    pupillary response    dassification model
收稿日期: 2021-05-14      出版日期: 2022-09-03
基金资助:高小榕,教授,E-mail:gxr-dea@tsinghua.edu.cn
引用本文:   
刘强墨, 何旭, 周佰顺, 吴昊霖, 张弛, 秦羽, 沈晓梅, 高小榕. 基于机器学习和瞳孔响应的简易高性能自闭症分类模型[J]. 清华大学学报(自然科学版), 2022, 62(10): 1730-1738.
LIU Qiangmo, HE Xu, ZHOU Baishun, WU Haolin, ZHANG Chi, QIN Yu, SHEN Xiaomei, GAO Xiaorong. Simple and high performance classification model for autism based on machine learning and pupillary response. Journal of Tsinghua University(Science and Technology), 2022, 62(10): 1730-1738.
链接本文:  
http://jst.tsinghuajournals.com/CN/10.16511/j.cnki.qhdxxb.2021.26.030  或          http://jst.tsinghuajournals.com/CN/Y2022/V62/I10/1730
  
  
  
  
  
  
  
  
  
  
  
  
  
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