Please wait a minute...
 首页  期刊介绍 期刊订阅 联系我们 横山亮次奖 百年刊庆
最新录用  |  预出版  |  当期目录  |  过刊浏览  |  阅读排行  |  下载排行  |  引用排行  |  横山亮次奖  |  百年刊庆
清华大学学报(自然科学版)  2023, Vol. 63 Issue (5): 811-817    DOI: 10.16511/j.cnki.qhdxxb.2022.26.040
  医疗设备 本期目录 | 过刊浏览 | 高级检索 |
基于Monte Carlo模拟的全身骨扫描SPECT专用准直器设计
王喆鑫1, 刘辉1, 程李1, 高丽蕾2, 吕振雷1, 江年铭2, 何作祥3, 刘亚强1
1. 清华大学 工程物理系, 北京 100084;
2. 北京永新医疗设备有限公司, 北京 102206;
3. 清华大学附属北京清华长庚医院, 北京, 100084
Design of dedicated collimator for whole-body bone scanning on single photon emission computed tomography based on Monte Carlo simulation
WANG Zhexin1, LIU Hui1, CHENG Li1, GAO Lilei2, LV Zhenlei1, JIANG Nianming2, HE Zuoxiang3, LIU Yaqiang1
1. Department of Engineering Physics, Tsinghua University, Beijing 100084, China;
2. Beijing Novel Medical Equipment Ltd., Beijing 102206, China;
3. Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 100084, China
全文: PDF(5133 KB)   HTML
输出: BibTeX | EndNote (RIS)      
摘要 单光子发射断层成像(single photon emission computed tomography,SPECT)是放射性核素骨显像的重要成像手段之一。为进一步优化临床上应用于骨显像的SPECT系统的探测灵敏度,降低骨扫描时间,提高骨扫描效率,该文在临床双探头SPECT系统的基础上,设计了高探测灵敏度的骨显像专用准直器。通过设计一系列不同的准直器参数,进行Monte Carlo仿真模拟,对不同准直器的探测灵敏度和图像分辨率进行评估,以验证准直器的几何参数与性能的关系,选出一套准直器的设计方案,并用热圆柱模型实验验证了该准直器的成像效果。结果表明:该准直器在保证图像质量的同时,能显著降低骨扫描的采集时间。
E-mail Alert
关键词 全身骨扫描单光子发射断层成像高灵敏度准直器设计Monte Carlo模拟    
Abstract:[Objective] Single photon emission computed tomography (SPECT) is an important imaging method of radionuclide bone imaging. It can obtain noninvasive three-dimensional functional images for early diagnosis and staged prognostic evaluation of disease by detecting γ photons emitted by radioactive drugs in the human body. According to the results of the national nuclear medicine census in 2020, more than 60% of SPECT clinical examinations in China are bone system examinations, indicating a great demand for bone imaging. Bone system examination generally refers to bone scanning, which is a nuclear medical imaging examination for systemic bones and can effectively diagnose various primary or secondary bone tumors. However, the low-energy general-purpose parallel-hole collimator, which is clinically used for SPECT bone scanning, has a low detection sensitivity, which leads to low patient comfort and scanning efficiency. Thus, this study aimes to optimize the detection sensitivity of SPECT system for bone imaging in clinical practice, which can not only reduce bone scanning time but also improve bone scanning efficiency and increase clinical-conomic benefits.[Methods] Based on the clinical dual-head SPECT system, this paper designed a specific collimator for bone imaging with high detection sensitivity. This study focuses on simulation experiments, including the construction of an overall simulation system, design of collimator parameters, and performance evaluation. The overall simulation system refers to the parameters of the SPECT system developed by this paper's cooperative company. In collimator parameter design, based on the formula derived in theory, which guides this paper in identifying the factors related to the detection sensitivity and resolution of SPECT system, different collimator parameters are tested by changing the collimator thickness, hole spacing, and hole diameter. Then, a Monte Carlo simulation, which is supported by center of high performance computing, Tsinghua University, is conducted with a point source for performance evaluation, including the detection sensitivity and image spatial resolution.[Results] The results indicates that the relationship between the geometric parameters and performance of the collimator matched well with the theoretical formula:as the increase of hole septal increases, the effective area of photon penetration on the collimator decreases, which reduces the detection sensitivity, while there is no obvious change in the image resolution. As the aperture increases, the collimation effect of the collimator is weakened, resulting in a serious decline in resolution. However, more scintillation photons will reach the scintillation crystal, there by hugely improving the detection sensitivity. When the aperture becomes larger, the improvement in detection sensitivity cannot make up for the loss brought by the reduction in resolution. When the collimator thickens, the collimation effect is enhanced, and the number of oblique incident photons that can be detected is reduced, so the detection sensitivity shows a downward trend. However, the image resolution can be improved.[Conclusions] Thinning the collimator and hole diameter is feasible in designing the SPECT collimator for bone scanning. According to the results of the performance evaluation, a collimator design (collimator thickness, 25.5 mm; hole septal, 0.15 mm; hole diameter, 0.5 mm) is empirically selected. It has a detection sensitivity of 183 cpm/μCi and a spatial resolution of 13.6 mm, which can significantly reduce the bone scanning acquisition time while ensuring image quality. The imaging effect of the collimator is evaluated using a hot-rod phantom experiment. The results show that hot rods with a 5.5-mm diameter could be distinguished, demonstrating the imaging performance of our proposed dedicated collimator design for bone scanning.
Key wordswhole-body bone scanning    single photon emission computed tomography    high sensitivity    collimator design    Monte Carlo simulation
收稿日期: 2022-06-07      出版日期: 2023-04-23
通讯作者: 刘辉,助理研究员,      E-mail:
作者简介: 王喆鑫(1997—),男,硕士研究生。
王喆鑫, 刘辉, 程李, 高丽蕾, 吕振雷, 江年铭, 何作祥, 刘亚强. 基于Monte Carlo模拟的全身骨扫描SPECT专用准直器设计[J]. 清华大学学报(自然科学版), 2023, 63(5): 811-817.
WANG Zhexin, LIU Hui, CHENG Li, GAO Lilei, LV Zhenlei, JIANG Nianming, HE Zuoxiang, LIU Yaqiang. Design of dedicated collimator for whole-body bone scanning on single photon emission computed tomography based on Monte Carlo simulation. Journal of Tsinghua University(Science and Technology), 2023, 63(5): 811-817.
链接本文:  或
[1] 马天予. 单光子发射断层成像的系统建模与物理因素校正研究[D]. 北京:清华大学, 2004. MA T Y. Studies on system modeling and correction for physical factors in single photon emission computed tomography[D]. Beijing:Tsinghua University, 2004. (in Chinese)
[2] 中华医学会核医学分会. 2020年全国核医学现状普查结果简报[J]. 中华核医学与分子影像杂志, 2020, 40(12):747-749. Chinese Society of Nuclear Medicine. A brief report on the results of the national survey of nuclear medicine in 2020[J]. Chinese Journal of Nuclear Medicine and Molecular Imaging, 2020, 40(12):747-749. (in Chinese)
[3] 中华医学会. 临床技术操作规范·核医学分册[M]. 北京:人民军医出版社, 2004. Chinese Medical Association. Clinical technical operation specification:Nuclear medicine volume[M]. Beijing:People's Military Medical Press, 2004. (in Chinese)
[4] SAVELLI G, MAFFIOLI L, MACCAURO M, et al. Bone scintigraphy and the added value of SPECT (single photon emission tomography) in detecting skeletal lesions[J]. The Quarterly Journal of Nuclear Medicine:Official publication of the Italian Association of Nuclear Medicine (AIMN) and the International Association of Radiopharmacology (IAR), 2001, 45(1):27-37.
[5] WU J, LIU C. Recent advances in cardiac SPECT instrumentation and imaging methods[J]. Physics in Medicine & Biology, 2019, 64(6):06TR01.
[6] 孙立风, 吕振雷, 侯岩松, 等. 多针孔心脏SPECT成像系统设计与性能评估[J]. 原子能科学技术, 2021, 55(S2):407-413. SUN L F, Lü Z L, HOU Y S, et al. System design and performance evaluation for cardiac SPECT imaging with multi-pinhole collimator[J]. Atomic Energy Science and Technology, 2021, 55(S2):407-413. (in Chinese)
[7] SHIBUTANI T, ONOGUCHI M, YONEYAMA H, et al. Performance of swiftscan planar and single photon emission computed tomography technology using low-energy high-resolution and sensitivity collimator[R/OL]. (2020-04-29)[2022-03-05].
[8] THIBAULT F, BAILLY M, LE ROUZIC G, et al. Clinical evaluation of general electric new swiftscan solution in bone scintigraphy on NaI-camera:A head to head comparison with siemens symbia[J]. PLOS ONE, 2019, 14(9):e0222490.
[9] CHERRY S R, SORENSON J A, PHELPS M E. Physics in nuclear medicine[M]. 4th ed. Philadelphia:Elsevier Saunders, 2012.
[10] MATHER R L. Gamma-ray collimator penetration and scattering effects[J]. Journal of Applied Physics, 1957, 28(10):1200-1207.
[11] VAN AUDENHAEGE K, VAN HOLEN R, VANDENBERGHE S, et al. Review of SPECT collimator selection, optimization, and fabrication for clinical and preclinical imaging[J]. Medical Physics, 2015, 42(8):4796-4813.
[12] O'CONNOR M K, BROWN M L, HUNG J C, et al. The art of bone scintigraphy:Technical aspects[J]. Journal of Nuclear Medicine, 1991, 32(12):2332-2341.
[13] INOUE Y, SUZUKI A, SHIROUZU I, et al. Effect of collimator choice on quantitative assessment of cardiac iodine 123 MIBG uptake[J]. Journal of Nuclear Cardiology, 2003, 10(6):623-632.
[14] JAN S, SANTIN G, STRUL D, et al. GATE:A simulation toolkit for PET and SPECT[J]. Physics in Medicine & Biology, 2004, 49(19):4543-4561.
[15] 曾更生. 医学图像重建[M]. 北京:高等教育出版社, 2010. ZENG G S. Medical image reconstruction[M]. Beijing:Higher Education Press, 2010. (in Chinese)
[16] JACOBS F, SUNDERMANN E, DE SUTTER B, et al. A fast algorithm to calculate the exact radiological path through a pixel or voxel space[J]. Journal of Computing and Information Technology, 1998, 6(1):89-94.
[17] 茆诗松, 王静龙, 濮晓龙. 高等数理统计[M]. 北京:高等教育出版社, 1998. MAO S S, WANG J L, PU X L. Advanced mathematical statistics[M]. Beijing:Higher Education Press, 1998. (in Chinese)
[18] LIU X, LIU H, CHENG L, et al. A 3-dimensional stationary cascade gamma-ray coincidence imager[J]. Physics in Medicine & Biology, 2021, 66(22):225001.
[1] 赵丽, 何畅, 舒逸聃, 陈清林, 张冰剑. 丙烯/丙烷在分子筛上吸附热力学的Monte Carlo模拟[J]. 清华大学学报(自然科学版), 2023, 63(5): 714-722.
[2] 张旨晗, 刘辉, 吕振雷, 侯岩松, 孙立风, 王石, 吴朝霞, 刘亚强. 大动物SPECT系统设计与数值模拟[J]. 清华大学学报(自然科学版), 2022, 62(12): 1875-1883.
[3] 薛彦广, 邓晓梅, 苏贵良. 基于多属性逆向拍卖的工程担保分保竞拍[J]. 清华大学学报(自然科学版), 2018, 58(9): 841-848.
[4] 冯珂, 王守清, 薛彦广. 基于多方满意的PPP项目股权配置优化研究[J]. 清华大学学报(自然科学版), 2017, 57(4): 376-381.
[5] 邱彤, 陈金财, 方舟. 基于结构导向集总的石油馏分分子重构模型[J]. 清华大学学报(自然科学版), 2016, 56(4): 424-429.
[6] 陈宜正, 李君利, 邱睿, 武祯, 康玺. 医用加速器场所中子和感生γ光子剂量当量的计算分析[J]. 清华大学学报(自然科学版), 2016, 56(12): 1284-1289.
Full text



版权所有 © 《清华大学学报(自然科学版)》编辑部
本系统由北京玛格泰克科技发展有限公司设计开发 技术支持