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清华大学学报(自然科学版)  2015, Vol. 55 Issue (9): 1036-1044    
  生物与生物医学 本期目录 | 过刊浏览 | 高级检索 |
基于声卡的CAPs阈值和调谐曲线的快速方法
宫琴, 张硕越
清华大学 生物医学工程系, 北京 100084
Fast CAPs threshold and tuning curves based on a sound card detection system
GONG Qin, ZHANG Shuoyue
Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China
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摘要 听神经复合动作电位(CAPs)的阈值曲线和调谐曲线分别反映了听神经系统对刺激声的强度灵敏度和频率灵敏度。为快速、准确、客观地提取听神经系统的信息, 该文基于多媒体外置声卡CAPs检测系统平台, 使用 C#语言设计了CAPs阈值曲线和调谐曲线的快速检测算法。并通过豚鼠实验, 系统探讨了扫描方向、刺激声频率对快速CAPs调谐曲线的影响, 并与传统测试方法得到结果进行比较, 证明了快速测试方法的可靠性。该文还探讨了不同抑制准则、抑制声强度步长对于快速CAPs调谐曲线精确性的影响并验证了该系统的精确性。该系统为听神经复合动作电位的检测和后续研究提供了快速、客观、综合的分析研究平台。
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宫琴
张硕越
关键词 听神经复合动作电位(CAPs)阈值曲线调谐曲线快速方法    
Abstract:Auditory nerve compound action potentials (CAPs) threshold curves reflect the hearing sensitivity to intensity variations while its tuning curves reflect the sensitivity to frequency variations in the auditory nerve system. A fast CAPs threshold and tuning curve detection algorithm were developed based on an external multimedia sound card with C# to simplify the data extraction for studies of the auditory nerve system with more objective and more accurate information in a shorter time. The factors influencing the fast CAPs tuning curves such as the orientation of the sweeping frequency and the frequency of the stimulus were analyzed using guinea pig experiments. The fast CAPs threshold and tuning curves compare well with previous results. The factors contributing to fast CAPs tuning curve accuracy include reduction of the needed criteria and the rates of change for the masker intensity. This system is a fast, objective, and comprehensive analysis platform which will be valuable for further research on auditory nerve compound action potentials.
Key wordscompound action potentials (CAPs)    threshold curves    tuning curves    fast method
收稿日期: 2015-04-03      出版日期: 2015-11-09
ZTFLH:  R318.6  
通讯作者: 宫琴(1968-), 女(汉), 山东, 副教授。E-mail: gongqin@mail.tsinghua.edu.cn     E-mail: gongqin@mail.tsinghua.edu.cn
引用本文:   
宫琴, 张硕越. 基于声卡的CAPs阈值和调谐曲线的快速方法[J]. 清华大学学报(自然科学版), 2015, 55(9): 1036-1044.
GONG Qin, ZHANG Shuoyue. Fast CAPs threshold and tuning curves based on a sound card detection system. Journal of Tsinghua University(Science and Technology), 2015, 55(9): 1036-1044.
链接本文:  
http://jst.tsinghuajournals.com/CN/  或          http://jst.tsinghuajournals.com/CN/Y2015/V55/I9/1036
  图1 检测系统的组成框图
  图2 快速CAPs阈值曲线和快速CAP-TCs的声刺激时序
  图3 快速阈值曲线与传统阈值检测的比较
  图4 快速CAP-TCs结果处理与比较
  图5 不同刺激声频率的快速CAP-TC
  图6 不同扫描方向、刺激声频率的快速CAP-TCs的Q10dB
  图7 不同抑制准则的快速CAP-TCs
  图8 前向扫描中不同抑制声强度步长的快速CAP-TCs
  图9 反向扫描中不同抑制声强度步长的快速CAP-TCs
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[1] 王瑶,宫琴. 抑制准则值对刺激频率耳声发射抑制调谐曲线调谐特性的影响[J]. 清华大学学报(自然科学版), 2015, 55(1): 128-133.
[2] 宫琴, 黎婷婷, 刘帅. 一种基于声卡的CAPs检测系统的研制[J]. 清华大学学报(自然科学版), 2014, 54(5): 678-684.
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