Compound action potential and personalized parameter regulation of vagus nerve stimulation

doi:10.16511/j.cnki.qhdxxb.2017.22.004

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Abstract Vagus nerve stimulation (VNS) is widely used to treat various refractory diseases, such as epilepsy and depression. Personalized treatment is very important in these clinical applications. The intraoperative compound action potential (CAP) response of the vagus nerve is analyzed here to evaluate the personalized parameter regulation. A CAP detection system with in vivo experiments with pigs is used to analyze the relationship between the CAP and the VNS parameters, including the current amplitude, pulse width and frequency. The results indicate the selection criteria and the ranges of the stimulation parameters for individual-based treatment. Tests demonstrate that the personalized parameters of the VNS treatment for epilepsy and depression are based on the different response characteristics of the A and B components of the CAP. These results offer a foundation for improving the therapeutic efficacy and for developing closed-loop VNS therapies.

Keywords vagus nerve stimulation parameter regulation compound action potential personalized treatment in vivo experiment

ZTFLH:

R745.1+3

Issue Date: 15 February 2017

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	YUAN Yuan
	HAO Hongwei
	LI Luming

Cite this article:

YUAN Yuan,HAO Hongwei,LI Luming. Compound action potential and personalized parameter regulation of vagus nerve stimulation[J]. Journal of Tsinghua University(Science and Technology), 2017, 57(2): 134-140.

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http://jst.tsinghuajournals.com/EN/10.16511/j.cnki.qhdxxb.2017.22.004 OR http://jst.tsinghuajournals.com/EN/Y2017/V57/I2/134

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