Simulation of the optical stimulation mechanism of cochlear nerves

doi:10.16511/j.cnki.qhdxxb.2017.25.052

Download: PDF(1405 KB)
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks

Abstract There has been much research in recent years on pulsed laser stimulation to evoke auditory nerve responses. However, the mechanism is not yet fully understood. This paper describes use of the simulation software COMSOL Multiphysics to build a three-dimensional model to study both the photoacoustic and photo-thermal effect induced by the pulsed laser stimulation of the cochlea, combined with in vivo experiments on guinea pigs to analyze the mechanism. The simulations show that pulsed lasers cause a temperature rise, but also trigger a photoacoustic effect with the compound action potentials induced in guinea pigs deafened acutely by drugs. The results demonstrate that the response from optical stimulation is more likely the superposition of photoacoustic and photo-thermal effects.

Keywords cochlear implant pulsed laser mechanism simulation photoacoustic and photo-thermal effect

ZTFLH:

R318.6

Issue Date: 15 October 2017

	Service

	E-mail this article
	E-mail Alert
	RSS
	Articles by authors

	GUAN Tian
	YANG Muqun
	WEI Zikun
	JIANG Yucheng
	WANG Jian

Cite this article:

GUAN Tian,YANG Muqun,WEI Zikun, et al. Simulation of the optical stimulation mechanism of cochlear nerves[J]. Journal of Tsinghua University(Science and Technology), 2017, 57(10): 1102-1105.

URL:

http://jst.tsinghuajournals.com/EN/10.16511/j.cnki.qhdxxb.2017.25.052 OR http://jst.tsinghuajournals.com/EN/Y2017/V57/I10/1102

[1]	Olusanya B O, Neumann K J, Saunders J E. The global burden of disabling hearing impairment:A call to action[J]. Bulletin of the World Health Organization, 2014, 92(5):367-373.
[2]	Clark G M. The multi-channel cochlear implant:Multi-disciplinary development of electrical stimulation of the cochlea and the resulting clinical benefit[J]. Hearing Research, 2015, 322:4-13. url: http://dx.doi.org/10.1016/j.heares.2014.08.002
[3]	Duckert L G, Miller J M. Acute morphological changes in guinea pig cochlea following electrical stimulation a preliminary scanning electron microscope study[J]. Annals of Otology, Rhinology & Laryngology, 1982, 91(1):33-40. url: http://dx.doi.org/s of Otology, Rhinology
[4]	Counter S A. Electromagnetic stimulation of the auditory system:Effects and side-effects[J]. Scandinavian Audiology Supplementum, 1992, 37:1-32.
[5]	Izzo A D, Richter C P, Jansen E D, et al. Laser stimulation of the auditory nerve[J]. Lasers in Surgery and Medicine, 2006, 38(8):745-753.
[6]	Young H K, TAN Xiaodong, NAN Xia, et al. Target structures for cochlear infrared neural stimulation[J]. Canadian Journal of Physics, 2014, 92(7/8):675-680.
[7]	Izzo A D, Bendett M, Jansen E D, et al. Laser stimulation of auditory neurons at high-repetition rate[J]. Proceedings of SPIE-The International Society for Optical Engineering, 2007, 6435:64350R.
[8]	Izzo A D, Walsh J T, E Duco J, et al. Optical parameter variability in laser nerve stimulation:A study of pulse duration, repetition rate, and wavelength[J]. IEEE Transactions on Biomedical Engineering, 2007, 54(6):1108-1114.
[9]	Izzo A D, Walsh Jr J T, Ralph H, et al. Laser stimulation of the auditory system at 1.94μm and microsecond pulse durations[J]. Optical Interactions with Tissue and Cells, 2008, 6854:43-49.
[10]	Izzo A D, Jr W J, Ralph H, et al. Laser stimulation of auditory neurons:Effect of shorter pulse duration and penetration depth[J]. Biophysical Journal, 2008, 94(8):3159-3166.
[11]	Richter C P, Rajguru S, Stafford R, et al. Radiant energy during infrared neural stimulation at the target structure[J]. Proceedings of SPIE-The International Society for Optical Engineering, 2013, 8565:85655P.
[12]	TAN Xiaodong, Rajguru S, Young H, et al. Radiant energy required for infrared neural stimulation[J]. Scientific Reports, 2015, 5:13273. url: http://dx.doi.org/10.1038/srep13273
[13]	Ingo Ulrik T, Hannes M, Claus-Peter R, et al. Acoustic events and "optophonic" cochlear responses induced by pulsed near-infrared laser[J]. IEEE Transactions on Bio-medical Engineering, 2011, 58(6):1648-1655.
[14]	Wenzel G, Balster S, Zhang K, et al. Green laser light activates the inner ear[J]. Systematic Reviews, 2014, 3(1):1-8.
[15]	XIA Nan, WANG Xing, GU Xin, et al. Pulsed 808 nm infrared laser stimulation of the auditory nerve in guinea pig cochlea[J]. Lasers in Medical Science, 2014, 29(1):343-349.
[16]	WANG Jingxuan, TIAN Lan, CHEN Li, et al. Applied technology in evoked auditory response in vivo animal cochlea by 980 nm pulsed laser light[J]. Advanced Materials Research, 2014, 886:355-358. url: http://dx.doi.org/10.4028/www.scientific.net/AMR.886.355
[17]	GUAN Tian, ZHU Kai, CHEN Fei, et al. Auditory nerve impulses induced by 980 nm laser[J]. Journal of Biomedical Optics, 2015, 20(8), 088004.
[18]	关添, 吴默村, 朱凯, 等. 980 nm脉冲激光诱发听神经冲动[J]. 清华大学学报(自然科学版), 2015, 55(6):700-704.GUAN Tian, WU Mocun, ZHU Kai, et al. 980 nm pulsed laser-induced auditory nerve impulses[J]. Journal of Tsinghua University (Science and Technology), 2015, 55(6):700-704.(in Chinese)
[19]	戚诒让, 张德勇, 许龙江. 液体中的激光超声脉冲[J]. 自然杂志, 2003, 25(2):63-70.QI Yirang, ZHANG Deyong, XU LongJiang. Ultrasonic pulse excited by laser in liquid[J]. Chinese Journal of Nature, 2003, 25(2):63-70. (in Chinese)