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Journal of Tsinghua University(Science and Technology)    2014, Vol. 54 Issue (2) : 153-158     DOI:
Orginal Article |
Distribution of thermo seeds in magnetic induction therapy based on the simulated annealing algorithm
Dongyang CAI,Zihan ZHUO,Jie WANG,Jian'an WU,Jintian TANG()
Key Laboratory of Particle and Radiation Imaging of Ministry of Education, Tsinghua University, Beijing 100084, China
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Abstract  

Optimum distribution of the thermo seeds in a tumor is key to magnetic induction therapy planning. The core objective is to achieve the desired temperature distribution using the minimum number of thermo seeds. The optimum distribution of the thermo seeds is found using the simulated annealing (SA) algorithm combined with bio-heat production and transfer theory. This paper describes the calculational method to solve for the distribution of thermo seeds using the SA algorithm, including the design of the thermo seed distribution model, the bio-heat production and transfer model and the SA scheme. The algorithm is designed for the thermo seed distribution, initial temperature, stop condition, evaluation functions, acceptance probability and annealing strategy. The modeling and meshing of the tumor region, the modeling of the thermo seed implantation, the temperature distribution, and the iteration process are all introduced to show the feasibility of solving for the thermo seed distribution using the SA algorithm.

Keywords magnetic induction therapy      simulated annealing algorithm      thermo seed      bio-heat transfer     
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Issue Date: 15 February 2014
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Dongyang CAI
Zihan ZHUO
Jie WANG
Jian'an WU
Jintian TANG
Cite this article:   
Dongyang CAI,Zihan ZHUO,Jie WANG, et al. Distribution of thermo seeds in magnetic induction therapy based on the simulated annealing algorithm[J]. Journal of Tsinghua University(Science and Technology), 2014, 54(2): 153-158.
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http://jst.tsinghuajournals.com/EN/     OR     http://jst.tsinghuajournals.com/EN/Y2014/V54/I2/153
参数
直径/mm 0.8±0.02
长度/mm 6±0.1
单颗质量/mg 25±0.1
电导率/(S·m) (2.3±0.08)×106
Curie温度/℃ 76
比热容/(J·kg-1·K-1) 439±20
  
参数 计算值
组织热导率/(W·m-1·K-1) 0.5
血液比热容/(J·kg-1·K-1) 3 639
血液灌注率/(kg·m-3·s-1) 1
动脉血温度/℃ 37
交变磁场频率/kHz 100
热籽最大磁导率 1.885×10-4
Curie点附近曲线斜率系数 0.4
交变磁场磁场强度/(kA·m-1) 2
  
  
  
  
  
迭代次数 热籽数量 计算结果/% 评价函数计算结果
0 148 0 0.93
100 141 0 0.87
500 115 0 0.74
1 000 81 0 0.56
1 350 58 0 0.43
1 365 57 67 0
  
  
  
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