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Abstract Clinical implementation of magnetic induction hyperthermia (MIH) seeks to conformally killing tumor cells while protecting the normal tissue. Thus, the temperature distribution in the treatment area needs to be accurately simulated by the preoperative treatment planning systems (TPS) to help the surgeon make an appropriate clinical plan to ensure the safety and efficacy of the MIH therapy. Medical image open source toolkits, such as VTK and ITK, can give accurate 3-D reconstruction, visualization and segmentation of tumors and their surrounding tissue from 2-D CT images. Then, ferromagnetic thermoseeds are implanted into the tumor region. Electromagnetism and bio-heat transfer theories are used to predict the energy fields generated by the thermoseeds and the temperature distributions due to the heat diffusion in the MIH process. This conformal-hyperthermia method can be applied in magnetic induction hyperthermia treatment planning systems (MHTPS). The results show that the conformal-hyperthermia method in MHTPS can help surgeons intuitively segment tumors, accurately predict the temperature distributions in the treatment area, and make reasonable preoperative plans.
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| Keywords
tumor hyperthermia
magnetic induction therapy
preoperative planning
modeling and simulation
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Issue Date: 15 June 2014
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2014,
Vol. 54
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