宿主无损光照消毒技术综述

张婉清; 苏萍; 马建设; 巩马理

doi:10.16511/j.cnki.qhdxxb.2023.21.011

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清华大学学报（自然科学版） ›› 2024, Vol. 64 ›› Issue (2) : 370-380. DOI: 10.16511/j.cnki.qhdxxb.2023.21.011

生物医学工程

宿主无损光照消毒技术综述

张婉清¹, 苏萍¹, 马建设¹, 巩马理^1,2

作者信息 +

Review of light-based host-nondestructive disinfection

ZHANG Wanqing¹, SU Ping¹, MA Jianshe¹, GONG Mali^1,2

Author information +

文章历史 +

摘要

细菌、病毒等病原体给人类社会造成巨大危害。化学药剂、热能和紫外线被广泛应用于灭活有害微生物，但这些方法也会对病原体的宿主产生无差别伤害。宿主无损光照消毒技术能够在不损伤宿主细胞的同时灭活病原体，因而受到越来越多的关注。目前主流的宿主无损光照消毒技术包括207～222 nm远紫外线（far-ultraviolet C，far-UVC）、抗菌蓝光（antibacterial blue light）和低功率超短脉冲激光消毒。该文综述了这3种技术的基本原理、研究动态、适用场景和优缺点；对比了宿主无损光照消毒技术与传统紫外线消毒技术的技术特点；从理论模型建立和实际应用2方面提出了宿主无损光照消毒技术的研究展望。宿主无损光照消毒技术将有助于阻止大规模疫情中有害病原体的传播，可为食品保鲜和医疗产品消毒提供一种新方案，具有广阔的应用前景。

Abstract

[Significance] Pathogens have caused numerous, large, and deadly outbreaks, and various disinfection techniques have been applied to stop the spread of harmful pathogens. These techniques are classified as chemical and physical disinfection based on the principle of inactivation. However, the frequently used disinfection techniques can cause indiscriminate harm to the host. Ultraviolet (UV) light is the most popular light disinfection technique, followed by chemical, thermal, ionizing radiation, and thermal disinfection, which harm the pathogen-containing biological tissues by altering their protein or nucleic acid composition. These technologies are unsuitable for prolonged disinfection in the presence of human activity. Thus, there is a need to explore a disinfection technology that can be safely used on living beings for a prolonged period. The disinfection technique must inactivate the pathogen and protect the host from the pathogen but cause no harm to the host cells. Light-based host-nondestructive disinfection techniques specifically inactivate harmful pathogens without damaging the surrounding tissues and have important applications in space disinfection, disease treatment, food preservation, and biologics production. [Progress] Currently, far-UVC, antibacterial blue light, and low-power ultrashort pulse laser are some of the most widely used nondestructive light disinfection techniques. Far-UVC damages nucleic acids by forming cyclobutane pyrimidine dimers between thymine molecules in DNA/RNA, thereby eliminating the ability of pathogens to replicate and infect. The 207-222 nm far-UVC is considered safe as the short wavelength penetrates only the stratum corneum, the skin's outermost layer, and the outer surface of the eye. However, research on far-UVC is limited because applicable dose standards and inactivation kinetics are lacking. The disinfection ability of antibacterial blue light is due to the presence of certain endogenous photosensitizers inside microorganisms that absorb light energy, such as porphyrins and flavins. These endogenous photosensitizers convert some substances into reactive oxygen species (ROS), which destroy the internal structures, such as organelles, of the microorganism by oxidizing neighboring biomolecules and subsequently inactivating the microorganism. Currently, research on antimicrobial blue light has focused on bacterial and fungal disinfection, with limited research on the inactivation of viruses and protozoans. Because viruses do not have endogenous photosensitizers, antimicrobial blue light requires exogenous photosensitizers to inactivate the virus through the ROS mechanism. Low-power ultrashort pulse laser creates vibrations on the surface of pathogens using femtosecond-level light pulses to induce protein remodeling, which destroys the surface of pathogens and prevents infection. Different proteins differ in densities and vibration durations, so a low-power ultrashort pulse laser selectively inactivates pathogens by varying the pulse frequency without causing damage to other biological tissues. As the inactivation process does not produce unknown intermediates, it is safe to use in the production of vaccines, sterilization of blood products, and disinfection of cell culture medium. [Conclusions and Prospects] Light-based host-nondestructive disinfection techniques should be evaluated using the actual absorbed dose of microorganisms as the criterion for the inactivation effect, and a comprehensive light energy inactivation rate model should be established. It is necessary to explore the optimal light energy density, optimal inactivation wavelength, and multiwavelength and multimodal synergistic disinfection to promote the application of large-scale energy-efficient light inactivation technology to prevent the spread of pathogens.

导出引用

张婉清, 苏萍, 马建设, 巩马理. 宿主无损光照消毒技术综述[J]. 清华大学学报（自然科学版）. 2024, 64(2): 370-380 https://doi.org/10.16511/j.cnki.qhdxxb.2023.21.011

ZHANG Wanqing, SU Ping, MA Jianshe, GONG Mali. Review of light-based host-nondestructive disinfection[J]. Journal of Tsinghua University(Science and Technology). 2024, 64(2): 370-380 https://doi.org/10.16511/j.cnki.qhdxxb.2023.21.011

中图分类号： O439

参考文献

[1] Johns Hopkins University & Medicine. COVID-19 dashboard [EB/OL]. (2023-01-15) [2023-01-15]. https://coronavirus.jhu.edu/map.html.
[2] PANJWANI S, CUI I, SPETSIERIS K, et al. Application of machine learning methods to pathogen safety evaluation in biological manufacturing processes [J]. Biotechnology Progress, 2021, 37(3):e3135.
[3] NIE X B, LI Z H, LONG Y N, et al. Chlorine inactivation of Tubifex tubifex in drinking water and the synergistic effect of sequential inactivation with UV irradiation and chlorine [J]. Chemosphere, 2017, 177:7-14.
[4] PIRES R P S, GUIMARÃES J T, BARROS C P, et al. Ohmic heating increases inactivation and morphological changes of Salmonella sp. and the formation of bioactive compounds in infant formula [J]. Food Microbiology, 2021, 97:103737.
[5] DOWNES A, BLUNT T P. The influence of light upon the development of Bacteria [J]. Nature, 1877, 16(402):218-218.
[6] ENWEMEKA C S, BUMAH V V, MASSON-MEYERS D S. Light as a potential treatment for pandemic coronavirus infections:A perspective [J]. Journal of Photochemistry and Photobiology B:Biology, 2020, 207:111891.
[7] HEβLING M, HÖNES K, VATTER P, et al. Ultraviolet irradiation doses for coronavirus inactivation-review and analysis of coronavirus photoinactivation studies [J]. GMS Hygiene and Infection Control, 2020, 15:Doc08.
[8] O'FLAHERTY E, MEMBRÉ J M, CUMMINS E. Meta-analysis of the reduction of antibiotic-sensitive and antibiotic-resistant Escherichia coli as a result of low-and medium-pressure UV lamps [J]. Water Science & Technology, 2018, 2017(2):612-620.
[9] BARLAS S B, ADALIER N, DASDAG O, et al. Evaluation of SARS-CoV-2 with a biophysical perspective [J]. Biotechnology & Biotechnological Equipment, 2021, 35(1):392-406.
[10] SABINO C P, SELLERA F P, SALES-MEDINA D F, et al. UV-C (254 nm) lethal doses for SARS-CoV-2[J]. Photodiagnosis and Photodynamic Therapy, 2020, 32:101995.
[11] BIASIN M, BIANCO A, PARESCHI G, et al. UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication [J]. Scientific Reports, 2021, 11(1):6260.
[12] BOLTON J R, COTTON C A. The ultraviolet disinfection handbook [M]. Denver:American Water Works Association, 2008.
[13] BHARDWAJ S K, SINGH H, DEEP A, et al. UVC-based photoinactivation as an efficient tool to control the transmission of coronaviruses [J]. Science of the Total Environment, 2021, 792:148548.
[14] CHEN R Z, CRAIK S A, BOLTON J R. Comparison of the action spectra and relative DNA absorbance spectra of microorganisms:Information important for the determination of germicidal fluence (UV dose) in an ultraviolet disinfection of water [J]. Water Research, 2009, 43(20):5087-5096.
[15] NARDELL E A, BUCHER S J, BRICKNER P W, et al. Safety of upper-room ultraviolet germicidal air disinfection for room occupants:Results from the tuberculosis ultraviolet shelter study [J]. Public Health Reports, 2008, 123(1):52-60.
[16] WELCH D, BUONANNO M, GRILJ V, et al. Far-UVC light:A new tool to control the spread of airborne-mediated microbial diseases [J]. Scientific Reports, 2018, 8(1):2752.
[17] BUONANNO M, STANISLAUSKAS M, PONNAIYA B, et al. 207-nm UV light:A promising tool for safe low-cost reduction of surgical site infections. Ⅱ:In-vivo safety studies [J]. PLoS One, 2016, 11(6):e0138418.
[18] NARITA K, ASANO K, MORIMOTO Y, et al. Chronic irradiation with 222-nm UVC light induces neither DNA damage nor epidermal lesions in mouse skin, even at high doses [J]. PLoS One, 2018, 13(7):e0201259.
[19] YAMANO N, KUNISADA M, KAIDZU S, et al. Long-term effects of 222-nm ultraviolet radiation C sterilizing lamps on mice susceptible to ultraviolet radiation [J]. Photochemistry and Photobiology, 2020, 96(4):853-862.
[20] KAIDZU S, SUGIHARA K, SASAKI M, et al. Evaluation of acute corneal damage induced by 222-nm and 254-nm ultraviolet light in Sprague-Dawley rats [J]. Free Radical Research, 2019, 53(6):611-617.
[21] FUKUI T, NIIKURA T, ODA T, et al. Exploratory clinical trial on the safety and bactericidal effect of 222-nm ultraviolet C irradiation in healthy humans [J]. PLoS One, 2020, 15(8):e0235948.
[22] BUONANNO M, PONNAIYA B, WELCH D, et al. Germicidal efficacy and mammalian skin safety of 222-nm UV light [J]. Radiation Research, 2017, 187(4):493-501.
[23] RAEISZADEH M, ADELI B. A critical review on ultraviolet disinfection systems against COVID-19 outbreak:Applicability, validation, and safety considerations [J]. ACS Photonics, 2020, 7(11):2941-2951.
[24] BUONANNO M, WELCH D, SHURYAK I, et al. Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses [J]. Scientific Reports, 2020, 10(1):10285.
[25] SCHELLER C, KREBS F, MINKNER R, et al. Physicochemical properties of SARS-CoV-2 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality control [J]. Electrophoresis, 2020, 41(13-14):1137-1151.
[26] XIE M X, CHEN Q. Insight into 2019 novel coronavirus:An updated interim review and lessons from SARS-CoV and MERS-CoV [J]. International Journal of Infectious Diseases, 2020, 94:119-124.
[27] NARITA K, ASANO K, MORIMOTO Y, et al. Disinfection and healing effects of 222-nm UVC light on methicillin-resistant Staphylococcus aureus infection in mouse wounds [J]. Journal of Photochemistry and Photobiology B:Biology, 2018, 178:10-18.
[28] MATAFONOVA G G, BATOEV V B, ASTAKHOVA S A, et al. Efficiency of KrCl excilamp (222 nm) for inactivation of bacteria in suspension [J]. Letters in Applied Microbiology, 2008, 47(6):508-513.
[29] HA J W, LEE J I, KANG D H. Application of a 222-nm krypton-chlorine excilamp to control foodborne pathogens on sliced cheese surfaces and characterization of the bactericidal mechanisms [J]. International Journal of Food Microbiology, 2017, 243:96-102.
[30] KANG J W, LEE J I, JEONG S Y, et al. Effect of 222-nm krypton-chloride excilamp treatment on inactivation of Escherichia coli O157:H7 and Salmonella Typhimurium on alfalfa seeds and seed germination [J]. Food Microbiology, 2019, 82:171-176.
[31] RAEISZADEH M, TAGHIPOUR F. Inactivation of microorganisms by newly emerged microplasma UV lamps [J]. Chemical Engineering Journal, 2021, 413:127490.
[32] ARAUD E, FUZAWA M, SHISLER J L, et al. UV inactivation of rotavirus and Tulane virus targets different components of the Virions [J]. Applied and Environmental Microbiology, 2020, 86(4):e02436-19.
[33] KITAGAWA H, NOMURA T, NAZMUL T, et al. Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination [J]. American Journal of Infection Control, 2021, 49(3):299-301.
[34] CLAUß M. Higher effectiveness of photoinactivation of bacterial spores, UV resistant vegetative bacteria and mold spores with 222 nm compared to 254 nm wavelength [J]. Acta Hydrochimica et Hydrobiologica, 2006, 34(6):525-532.
[35] NARITA K, ASANO K, NAITO K, et al. Ultraviolet C light with wavelength of 222 nm inactivates a wide spectrum of microbial pathogens [J]. Journal of Hospital Infection, 2020, 105(3):459-467.
[36] BRANTNER C, WONG A, DAVIS A L, et al. Safety of 222 nm band-pass filtered irradiation:A review and analysis of current data [EB/OL]. (2020-12-07) [2023-04-11]. https://www.boeing.com/confident-travel/downloads/Boeing_Safety_of_222_nm_Band-Pass_Filtered_Irradiation.pdf.
[37] The International Organization for Standardization. UV-C devices-safety information-permissible human exposure:ISO 15858:2016. [OL] (2016-07-15) [2023-04-11]. https://www.iso.org/obp/ui/#iso:std:iso:15858:ed-1:v1:en.
[38] RAAB O. Uber die wirkung fluorescirender stoffe auf infusorien [J]. Zeitschrift für Biologie, 1900, 39:524-546.
[39] JESIONEK A, VON TAPPEINER H. Zur behandlung der hautcarcinome mit fluorescierenden stoffen [J]. Dtsch Arch Klin Med, 1905, 82:223-227.
[40] YU PLAVSKII V, MIKULICH A V, TRETYAKOVA A I, et al. Porphyrins and flavins as endogenous acceptors of optical radiation of blue spectral region determining photoinactivation of microbial cells [J]. Journal of Photochemistry and Photobiology B:Biology, 2018, 183:172-183.
[41] WANG Y C, WANG Y, WANG Y G, et al. Antimicrobial blue light inactivation of pathogenic microbes:State of the art [J]. Drug Resistance Updates, 2017, 33-35:1-22.
[42] KIM M J, MIKŠ-KRAJNIK M, KUMAR A, et al. Antibacterial effect and mechanism of high-intensity 405±5 nm light emitting diode on Bacillus cereus, Listeria monocytogenes, and Staphylococcus aureus under refrigerated condition [J]. Journal of Photochemistry and Photobiology B:Biology, 2015, 153:33-39.
[43] FOOTE C S. Definition of type Ⅰ and type Ⅱ photosensitized oxidation [J]. Photochemistry and Photobiology, 1991, 54(5):659.
[44] DO PRADO-SILVA L, BRANCINI G T P, BRAGA GÚ L, et al. Antimicrobial photodynamic treatment (aPDT) as an innovative technology to control spoilage and pathogenic microorganisms in agri-food products:An updated review [J]. Food Control, 2022, 132:108527.
[45] HAMBLIN M R, ABRAHAMSE H. Oxygen-independent antimicrobial photoinactivation:Type Ⅲ photochemical mechanism? [J]. Antibiotics, 2020, 9(2):53.
[46] MACLEAN M, MACGREGOR S J, ANDERSON J G, et al. The role of oxygen in the visible-light inactivation of Staphylococcus aureus [J]. Journal of Photochemistry and Photobiology B:Biology, 2008, 92(3):180-184.
[47] MACLEAN M, MACGREGOR S J, ANDERSON J G, et al. High-intensity narrow-spectrum light inactivation and wavelength sensitivity of Staphylococcus aureus [J]. FEMS Microbiology Letters, 2008, 285(2):227-232.
[48] MACLEAN M, MCKENZIE K, ANDERSON J G, et al. 405 nm light technology for the inactivation of pathogens and its potential role for environmental disinfection and infection control [J]. Journal of Hospital Infection, 2014, 88(1):1-11.
[49] MACLEAN M, MACGREGOR S J, ANDERSON J G, et al. Inactivation of bacterial pathogens following exposure to light from a 405-nanometer light-emitting diode array [J]. Applied and Environmental Microbiology, 2009, 75(7):1932-1937.
[50] KUMAR A, GHATE V, KIM M J, et al. Kinetics of bacterial inactivation by 405 nm and 520 nm light emitting diodes and the role of endogenous coproporphyrin on bacterial susceptibility [J]. Journal of Photochemistry and Photobiology B:Biology, 2015, 149:37-44.
[51] MURDOCH L E, MACLEAN M, ENDARKO E, et al. Bactericidal effects of 405 nm light exposure demonstrated by inactivation of Escherichia, Salmonella, Shigella, Listeria, and Mycobacterium species in liquid suspensions and on exposed surfaces [J]. The Scientific World Journal, 2012, 2012:137805.
[52] HOENES K, BAUER R, MEURLE T, et al. Inactivation effect of violet and blue light on ESKAPE pathogens and closely related non-pathogenic bacterial species-a promising tool against antibiotic-sensitive and antibiotic-resistant microorganisms [J]. Frontiers in Microbiology, 2021, 11:612367.
[53] JOSEWIN S W, KIM M J, YUK H G. Inactivation of Listeria monocytogenes and Salmonella spp. on cantaloupe rinds by blue light emitting diodes (LEDs) [J]. Food Microbiology, 2018, 76:219-225.
[54] WANG Y, FERRER-ESPADA R, BAGLO Y, et al. Antimicrobial blue light inactivation of Neisseria gonorrhoeae:Roles of wavelength, endogenous photosensitizer, oxygen, and reactive oxygen species [J]. Lasers in Surgery and Medicine, 2019, 51(9):815-823.
[55] KIM M J, ADELINE NG B X, ZWE Y H, et al. Photodynamic inactivation of Salmonella enterica enteritidis by 405±5 nm light-emitting diode and its application to control salmonellosis on cooked chicken [J]. Food Control, 2017, 82:305-315.
[56] TOMB R M, MACLEAN M, HERRON P R, et al. Inactivation of Streptomyces phage ΦC31 by 405 nm light:Requirement for exogenous photosensitizers? [J]. Bacteriophage, 2014, 4(3):e32129.
[57] TOMB R M, MACLEAN M, COIA J E, et al. New proof-of-concept in viral inactivation:Virucidal efficacy of 405 nm light against feline calicivirus as a model for norovirus decontamination [J]. Food and Environmental Virology, 2017, 9(2):159-167.
[58] MURDOCH L E, MCKENZIE K, MACLEAN M, et al. Lethal effects of high-intensity violet 405-nm light on Saccharomyces cerevisiae, Candida albicans, and on dormant and germinating spores of Aspergillus niger [J]. Fungal Biology, 2013, 117(7-8):519-527.
[59] CHUA A, CHONG L, GHATE V, et al. Antifungal action of 405 nm light emitting diodes on tomatoes in a meso-scale system and their effect on the physicochemical properties [J]. Postharvest Biology and Technology, 2021, 172:111366.
[60] MCDONALD R, GRANT M H, MACGREGOR S J, et al. Effect of 405-nm high-intensity narrow-spectrum light on fibroblast-populated collagen lattices:An in vitro model of wound healing [J]. Journal of Biomedical Optics, 2011, 16(4):048003.
[61] DOS ANJOS C, LEANSE L G, LIU X J, et al. Antimicrobial blue light for prevention and treatment of highly invasive Vibrio vulnificus burn infection in mice [J]. Frontiers in Microbiology, 2022, 13:932466.
[62] LIU X J, CHANG Q H, FERRER-ESPADA R, et al. Photoinactivation of Moraxella catarrhalis using 405-nm blue light:Implications for the treatment of otitis media [J]. Photochemistry and Photobiology, 2020, 96(3):611-617.
[63] MACLEAN M, GELDERMAN M P, KULKARNI S, et al. Non-ionizing 405 nm light as a potential bactericidal technology for platelet safety:Evaluation of in vitro bacterial inactivation and in vivo platelet recovery in severe combined immunodeficient mice [J]. Frontiers in Medicine, 2020, 6:331.
[64] KIM M J, TANG C H, BANG W S, et al. Antibacterial effect of 405±5 nm light emitting diode illumination against Escherichia coli O157:H7, Listeria monocytogenes, and Salmonella on the surface of fresh-cut mango and its influence on fruit quality [J]. International Journal of Food Microbiology, 2017, 244:82-89.
[65] KIM M J, BANG W S, YUK H G. 405±5 nm light emitting diode illumination causes photodynamic inactivation of Salmonella spp. on fresh-cut papaya without deterioration [J]. Food Microbiology, 2017, 62:124-132.
[66] GHATE V, KUMAR A, KIM M J, et al. Effect of 460 nm light emitting diode illumination on survival of Salmonella spp. on fresh-cut pineapples at different irradiances and temperatures [J]. Journal of Food Engineering, 2017, 196:130-138.
[67] KIM M J, DA JEONG M, ZHENG Q W, et al. Antimicrobial activity of 405 nm light-emitting diode (LED) in the presence of riboflavin against Listeria monocytogenes on the surface of smoked salmon [J]. Food Science and Biotechnology, 2021, 30(4):609-618.
[68] LI X Z, KIM M J, YUK H G. Influence of 405nm light-emitting diode illumination on the inactivation of Listeria monocytogenes and Salmonella spp. on ready-to-eat fresh salmon surface at chilling storage for 8 h and their susceptibility to simulated gastric fluid [J]. Food Control, 2018, 88:61-68.
[69] DOS ANJOS C, SELLERA F P, DE FREITAS L M, et al. Inactivation of milk-borne pathogens by blue light exposure [J]. Journal of Dairy Science, 2020, 103(2):1261-1268.
[70] GIRARD P M, FRANCESCONI S, POZZEBON M, et al. UVA-induced damage to DNA and proteins:Direct versus indirect photochemical processes [J]. Journal of Physics:Conference Series, 2011, 261:012002.
[71] PATTISON D I, RAHMANTO A S, DAVIES M J. Photo-oxidation of proteins [J]. Photochemical & Photobiological Sciences, 2012, 11(1):38-53.
[72] NGUENHA R, DAMYEH M S, PHAN A D T, et al. Effect of photosensitization mediated by curcumin on carotenoid and aflatoxin content in different maize varieties [J]. Applied Sciences, 2021, 11(13):5902.
[73] BUCHOVEC I, LUKSEVICIŪTÉ V, KOKSTAITE R, et al. Inactivation of Gram (-) bacteria Salmonella enterica by chlorophyllin-based photosensitization:Mechanism of action and new strategies to enhance the inactivation efficiency [J]. Journal of Photochemistry and Photobiology B:Biology, 2017, 172:1-10.
[74] EICHNER A, GOLLMER A, SPÄTH A, et al. Fast and effective inactivation of Bacillus atrophaeus endospores using light-activated derivatives of vitamin B2[J]. Photochemical & Photobiological Sciences, 2015, 14(2):387-396.
[75] TSEN K T, TSEN S W D, CHANG C L, et al. Inactivation of viruses by coherent excitations with a low power visible femtosecond laser [J]. Virology Journal, 2007, 4(1):50.
[76] TSEN S W D, TSEN K T. Selective photonic disinfection:A ray of hope in the war against pathogens [M]. Bristol:IOP Publishing, 2016.
[77] TSEN S W D, CHAPA T, BEATTY W, et al. Inactivation of enveloped virus by laser-driven protein aggregation [J]. Journal of Biomedical Optics, 2012, 17(12):128002.
[78] TSEN S W D, KINGSLEY D H, KIBLER K, et al. Pathogen reduction in human plasma using an ultrashort pulsed laser [J]. PLoS One, 2014, 9(11):e111673.
[79] TSEN S W D, KINGSLEY D H, POWELEIT C, et al. Studies of inactivation mechanism of non-enveloped icosahedral virus by a visible ultrashort pulsed laser [J]. Virology Journal, 2014, 11(1):20.
[80] TSEN K T, TSEN S W D, FU Q, et al. Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser:Insight into the possible inactivation mechanisms [J]. Journal of Biomedical Optics, 2011, 16(7):078003.
[81] LU C H, LIN K H, HSU Y Y, et al. Inhibition of Escherichia coli respiratory enzymes by short visible femtosecond laser irradiation [J]. Journal of Physics D:Applied Physics, 2014, 47(31):315402.
[82] TSEN K T, TSEN S W D, FU Q, et al. Photonic approach to the selective inactivation of viruses with a near-infrared subpicosecond fiber laser [J]. Journal of Biomedical Optics, 2009, 14(6):064042.
[83] TSEN S W D, DONTHI N, LA V, et al. Chemical-free inactivated whole influenza virus vaccine prepared by ultrashort pulsed laser treatment [J]. Journal of Biomedical Optics, 2014, 20(5):051008.
[84] TSEN S W D, POPOVICH J, HODGES M, et al. Inactivation of multidrug-resistant bacteria and bacterial spores and generation of high-potency bacterial vaccines using ultrashort pulsed lasers [J]. Journal of Biophotonics, 2022, 15(2):e202100207.
[85] TSEN S W D, KIBLER K, JACOBS B, et al. Selective photonic disinfection of cell culture using a visible ultrashort pulsed laser [J]. IEEE Journal of Selected Topics in Quantum Electronics, 2016, 22(3):7100508.
[86] JANKOWSKA K I, NAGARKATTI R, ACHARYYA N, et al. Complete inactivation of blood borne pathogen Trypanosoma cruzi in stored human platelet concentrates and plasma treated with 405 nm violet-blue light [J]. Frontiers in Medicine, 2020, 7:617373.
[87] HIJNEN W A M, BEERENDONK E F, MEDEMA G J. Inactivation credit of UV radiation for viruses, bacteria and protozoan (oo)cysts in water:A review [J]. Water Research, 2006, 40(1):3-22.
[88] KAMAU D N, DOORES S, PRUITT K M. Enhanced thermal destruction of Listeria monocytogenes and Staphylococcus aureus by the lactoperoxidase system [J]. Applied and Environmental Microbiology, 1990, 56(9):2711-2716.
[89] MARUGÁN J, VAN GRIEKEN R, SORDO C, et al. Kinetics of the photocatalytic disinfection of Escherichia coli suspensions [J]. Applied Catalysis B:Environmental, 2008, 82(1-2):27-36.
[90] LINTON R H, CARTER W H, PIERSON M D, et al. Use of a modified gompertz equation to model nonlinear survival curves for Listeria monocytogenes Scott A [J]. Journal of Food Protection, 1995, 58(9):946-954.
[91] BIALKA K L, DEMIRCI A, PURI V M. Modeling the inactivation of Escherichia coli O157:H7 and Salmonella enterica on raspberries and strawberries resulting from exposure to ozone or pulsed UV-light [J]. Journal of Food Engineering, 2008, 85(3):444-449.
[92] DONG J F, WANG T F. Data driven modeling of the reactive oxygen species stimulated by photon energy in light therapies [J]. IEEE Access, 2020, 8:18196-18206.
[93] ZHANG W Q, SU P, MA J S, et al. A singlet state oxygen generation model based on the Monte Carlo method of visible antibacterial blue light inactivation [J]. Journal of Photochemistry and Photobiology B:Biology, 2023, 239:112628.
[94] HOENES K, WILD K, SCHMID J, et al. Microbial photoinactivation by 470 nm radiation:An investigation into the underlying photobiological mechanism [C]//Proceedings of SPIE 10479, Light-Based Diagnosis and Treatment of Infectious Diseases. San Francisco, USA:SPIE, 2018:142.
[95] LEANSE L G, GOH X S, CHENG J X, et al. Dual-wavelength photo-killing of methicillin-resistant Staphylococcus aureus [J]. JCI Insight, 2020, 5(11):e134343.
[96] KINGSLEY D, KUIS R, PEREZ R, et al. Oxygen-dependent laser inactivation of murine norovirus using visible light lasers [J]. Virology Journal, 2018, 15(1):117.

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