Development of lymphatic nodes in the Chinese reference adult male voxel model (CRAM) with applications to radionuclide therapy

LIU Huan; QIU Rui; PAN Yuxi; LI Junli

doi:10.16511/j.cnki.qhdxxb.2016.25.039

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Journal of Tsinghua University(Science and Technology) ›› 2016, Vol. 56 ›› Issue (12) : 1290-1296. DOI: 10.16511/j.cnki.qhdxxb.2016.25.039

PHYSICS AND ENGINEERING PHYSICS

Development of lymphatic nodes in the Chinese reference adult male voxel model (CRAM) with applications to radionuclide therapy

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Abstract

The dosages to lymphatic nodes are critical to evaluating the dose in lymphoma patients treated with radionuclide therapy in studies using human computational phantoms. Furthermore, the International Commission on Radiological Protection (ICRP) now considers the lymphatic nodes to be a radiosensitive tissue in ICRP Publication 103. Since lymphatic nodes are widely distribute the human body and are quite small, they are difficult to model in human computational models. This paper introduces a method that automatically develops lymphatic nodes in the Chinese reference adult male voxel model (CRAM). The S-values for ¹³¹I are calculated with the lymphatic nodes as the source organs and the other organs and tissues in the human body treated as the target regions. The CRAM model has a total of 17 lymphatic node sites. Both the number and mass of the lymphatic nodes accord with the Chinese reference values. The S-value calculation illustrates the dose assessment for radionuclide therapy and its value is related to the position of the lymphatic nodes and other organs and tissues in the human body.

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voxel phantom / lymphatic node / S-value / dose

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LIU Huan, QIU Rui, PAN Yuxi, LI Junli. Development of lymphatic nodes in the Chinese reference adult male voxel model (CRAM) with applications to radionuclide therapy[J]. Journal of Tsinghua University(Science and Technology). 2016, 56(12): 1290-1296 https://doi.org/10.16511/j.cnki.qhdxxb.2016.25.039

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