Design and numerical simulations of a large animal SPECT system

ZHANG Zhihan; LIU Hui; L?Zhenlei; HOU Yansong; SUN Lifeng; WANG Shi; WU Zhaoxia; LIU Yaqiang

doi:10.16511/j.cnki.qhdxxb.2021.26.041

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Journal of Tsinghua University(Science and Technology) ›› 2022, Vol. 62 ›› Issue (12) : 1875-1883. DOI: 10.16511/j.cnki.qhdxxb.2021.26.041

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Design and numerical simulations of a large animal SPECT system

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Abstract

This study analyzed the collimator parameters of a large animal single photon emission computed tomography (SPECT) detector. Six collimator design schemes were chosen by thoretical calculation of the spatial resolution, the sensitivity at the field of view (FOV) center and the projection overlap ratio with specified constraints. A performance evaluation method was used to evaluate the six collimator design schemes by calculating the contrast recovery coefficient (CRC) and the variance of the local impulse response of selected pixels to find the best design scheme. The imaging effect of the design scheme was verified by numerical simulations of imaging experiments of a hotrod phantom. The theoretical calculations and the numerical simulations demonstrate that the design scheme gives a spatial resolution of the hotrod phantom that is better than 3.0 mm with better than 0.03% sensitivity at the FOV center, which meets the technical requirements.

Key words

large animal SPECT system / performance evaluation method / collimator design schemes / numerical simulations

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ZHANG Zhihan, LIU Hui, L�Zhenlei, HOU Yansong, SUN Lifeng, WANG Shi, WU Zhaoxia, LIU Yaqiang. Design and numerical simulations of a large animal SPECT system[J]. Journal of Tsinghua University(Science and Technology). 2022, 62(12): 1875-1883 https://doi.org/10.16511/j.cnki.qhdxxb.2021.26.041

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