清华大学能源与动力工程系人工心脏研究进展

黄博, 李浩源, 陆斌, 左志钢, 罗先武, 刘树红

清华大学学报（自然科学版） ›› 2022, Vol. 62 ›› Issue (4) : 746-757.

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清华大学学报（自然科学版） ›› 2022, Vol. 62 ›› Issue (4) : 746-757. DOI: 10.16511/j.cnki.qhdxxb.2022.25.030
综述

清华大学能源与动力工程系人工心脏研究进展

  • 黄博1, 李浩源1, 陆斌2, 左志钢1, 罗先武1, 刘树红1
作者信息 +

Advances in the development of Artificial Hearts in the Department of Energy and Power Engineering of Tsinghua University

  • HUANG Bo1, LI Haoyuan1, LU Bin2, ZUO Zhigang1, LUO Xianwu1, LIU Shuhong1
Author information +
文章历史 +

摘要

离心式血泵作为最新一代人工心脏,为心血管疾病患者提供了有效的生命支持系统,挽救了数以百万计的心脏病患者的生命。该文对清华大学能源与动力工程系(简称能动系)团队在人工心脏领域的研发进展进行了详细介绍,包括：提出了以最大标量剪切应力(maximum scalar shear stress,MSSS)代替标准溶血指数作为优化指标的优化方法,减少了计算量,提升了优化效率;提出了基于湍流黏性耗散应力(turbulent viscous shear stress,TVSS)的血细胞损伤模型,以便更为准确地预测血细胞的损伤等。在人工心脏样机方面,顺利完成了体外式轴承和植入式磁液混合悬浮两种样机的研制,并获得了相应水力性能数据,实验数据与计算结果吻合较好,误差为3.6%。为了进一步推进样机研发,本研究团队搭建了医用流体机械综合测试平台,可用于测试人工心脏的生理性能。上述研究成果体现了清华大学能动系在人工心脏自主研发技术上取得的重要进展。

Abstract

The latest generation of Artificial Hearts are using centrifugal blood pumps to provide important support for patients with cardiovascular diseases. This paper describes the advances in the development of Artificial Hearts in the Department of Energy and Power Engineering of Tsinghua University. A pump design optimization method was proposed based on the maximum scalar shear stress for the hemolysis standard to raduce the calculational load and improve the optimization efficiency. A blood-cell-damage model based on the turbulent viscous dissipative stress was developed for better prediction. Both extracorporeal pumps with bearings and left ventricular assist device (LVAD) prototypes with magneto-hydraulic suspensions have been developed with studies of their hydraulics. Model predictions agree with the experimental data with an error of 3.6%. A medical fluid flow experimental system has been developed to improve research on Artificial Heart prototypes through evaluations of the physiological effects of new Artificial Heart designs.

关键词

人工心脏 / 离心泵 / 水力性能 / 溶血

Key words

Artificial Hearts / centrifugal pumps / hydrodynamics / hemolysis

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黄博, 李浩源, 陆斌, 左志钢, 罗先武, 刘树红. 清华大学能源与动力工程系人工心脏研究进展[J]. 清华大学学报（自然科学版）. 2022, 62(4): 746-757 https://doi.org/10.16511/j.cnki.qhdxxb.2022.25.030
HUANG Bo, LI Haoyuan, LU Bin, ZUO Zhigang, LUO Xianwu, LIU Shuhong. Advances in the development of Artificial Hearts in the Department of Energy and Power Engineering of Tsinghua University[J]. Journal of Tsinghua University(Science and Technology). 2022, 62(4): 746-757 https://doi.org/10.16511/j.cnki.qhdxxb.2022.25.030

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基金

左志钢,副研究员,E-mail:zhigang200@mail.tsinghua.edu.cn;刘树红,教授,E-mail:liushuhong@mail.tsinghua.edu.cn

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