980 nm脉冲激光诱发听神经冲动

关添; 吴默村; 朱凯; 王健

PDF(1245 KB)

清华大学学报（自然科学版） ›› 2015, Vol. 55 ›› Issue (6) : 700-704.

生物与生物医学

980 nm脉冲激光诱发听神经冲动

关添¹, 吴默村^1,2, 朱凯^1,2, 王健³

作者信息 +

980 nm pulsed laser-induced auditory nerve impulses

GUAN Tian¹, WU Mocun^1,2, ZHU Kai^1,2, WANG Jian³

Author information +

文章历史 +

摘要

为了最优化选取刺激人工耳蜗激光参数,该文选用波段980 nm脉冲激光刺激豚鼠听神经,成功诱发了光刺激复合动作电位(optical compound action potentials, oCAPs); 通过分析实验结果表明: 光刺激具有一定的安全性,其刺激强度不是越大越好,存在一个最佳区域范围。

Abstract

A 980 nm near infrared laser was used to stimulate the auditory nerve in guinea pig cochlea to provide useful optical parameters for the development of an optical cochlear implant. The 980 nm pulsed laser can evoke optical compound action potentials (oCAPs) from guinea pig cochlea. The experimental results also demonstrate the security of optical stimulus and larger optical intensities not always giving better results.

导出引用

关添, 吴默村, 朱凯, 王健. 980 nm脉冲激光诱发听神经冲动[J]. 清华大学学报（自然科学版）. 2015, 55(6): 700-704

GUAN Tian, WU Mocun, ZHU Kai, WANG Jian. 980 nm pulsed laser-induced auditory nerve impulses[J]. Journal of Tsinghua University(Science and Technology). 2015, 55(6): 700-704

中图分类号： R318.6

参考文献

[1] ZENG Fangang, Rebscher S. Cochlear implants: System design, integration and evaluation [J]. IEEE Reviews in Biomedical Engineering,2008, 1: 115-142.
[2] Jonathon W, Chris K, Jansen E D, et al. Application of infrared light for in vivo neural stimulation [J]. Journal of Biomedical Optics, 2005, 10 (6): 1-12.
[3] 郗昕, 翼飞, 洪梦迪. 人工耳蜗技术报告(Ⅱ): 人工耳蜗团队 [J]. 中国听力语言康复科学杂志, 2006 (6): 36-37. XI Xin, YI Fei, HONG Mengdi. Cochlear technical report(Ⅱ): Cochlear team [J]. Chinese Scientific Journal of Hearing and Speech Rehabilitation, 2006 (6): 36-37. (in Chinese)
[4] Laura E M, Suhrud M R, Agnella D I, et al. Infrared neural stimulation: Beam path in the guinea pig cochlea [J]. Hearing Research, 2011, 6(6): 289-302.
[5] Arvanitaki A, Chalazonitis N. Excitatiory and Inhibitory Processes Initiated by Light and Infra-Red Radiations in Single Identifiable Nerve Cells [M]. Florey E, ed. Nervous Inhibition. New York, USA: Pergamum Press, 1961, 194-231.
[6] Fork R L. Laser stimulation of nerve cells in aplysia [J]. Science, 1971, 171(974): 907-908.
[7] Hirase H, Nikolenko V, Goldberg J H, et al. Multiphoton stimulation of neurons [J]. Journal of Neurobiology, 2002, 51(3): 237-247.
[8] Wells J, Kao C, Mariappan K, et al. Optical stimulation of neural tissue in vivo [J]. Optics Letters, 2005, 31: 235-238.
[9] Izzo A D, Richter C P, Jansen E D, et al. Laser stimulation of the auditory nerve [J]. Lasers in Surgery and Medicine, 2006, 38(8): 745-753.
[10] Izzo A D, Walsh J T, Ralph H, et al. Laser stimulation of auditory neurons: Effect of shorter pulse duration and penetration depth [J]. Biophysical Journal, 2008, 94(8): 3159-3166.
[11] Izzo A D, Joseph T W, Jim W, et al. Laser stimulation of the auditory system at 1.94 μm and microsecond pulse durations [J]. Optical Interactions with Tissue and Cells, 2008, 6854: 43-49.
[12] Richter C P, Rodrigo B, Izzo A D, et al. Optical stimulation of auditory neurons: Effects of acute and chronic deafening [J]. Hearing Research, 2008, 1(11): 42-51.
[13] Matic A I, Walsh J T, Richter C P. Spatial extent of cochlear infrared neural stimulation determined by tone-on-light masking [J]. Journal of Biomedical Optics, 2011, 16(11): 1-9.
[14] Wenzel G I, Balster S, ZHANG Kaiyin, et al. Green laser light activates the inner ear [J]. Journal of Biomedical Optics, 2009, 14(4): 4004-4007.
[15] Izzo A D, Joseph T W, Heather R, et al. Laser stimulation of auditory neurons: Effect of shorter pulse duration and penetration depth [J]. Biophysical Journal, 2008, 94: 3159-3166.
[16] XIA Nan, WANG Xing, GU Xin, et al. Pulsed 808-nm infrared laser stimulation of theauditory nerve in guinea pig cochlea [J]. Lasers in Medical Science, 2014, 29(1): 343-349.
[17] Jonathon W, Chris K, Peter K, et al. Biophysical mechanisms of transient optical stimulation of peripheral nerve [J]. Biophysical Journal, 2007, 93: 2567-2580.
[18] Izzo A D, Joseph T W, Heather R, et al. Optical parameter variability in laser nerve stimulation: A study of pulse duration, repetition rate and wavelength [J]. IEEE Transactions on Biomedical Engineering, 2007, 54(6): 1108-1113.

PDF(1245 KB)

Accesses

Citation

Detail

段落导航

收稿日期	出版日期
2015-01-07	2015-06-15
发布日期
2015-06-15

选择文件类型/文献管理软件名称

选择包含的内容

摘要

Abstract

关键词

Key words

引用本文

{{custom_sec.title}}

{{custom_sec.title}}

参考文献

访问统计

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

摘要

Abstract

关键词

Key words

引用本文

{{custom_sec.title}}

{{custom_sec.title}}

参考文献

访问统计