Objective: This study examines the wind-resistant design of the Shenzhen-Zhongshan Link located in the Pearl River Delta, an area prone to strong typhoons. The region can experience a maximum 10 min average wind speed of 43.0 m/s at a height of 10 m during a 100-year return period, posing significant challenges for bridge design. The aim is to propose a series of aerodynamic and mechanical control countermeasures to comprehensively mitigate wind-induced vibration risks during the operational lifespan of bridges. The main navigable span, the Lingdingyang Bridge, faces flutter risk, whereas the six-span nonnavigable span, featuring parallel twin box girders, is susceptible to vortex-induced vibration (VIV). Methods: The flutter performance of the two Lingdingyang Bridge design schemes is evaluated by conducting wind tunnel tests on a sectional model with a geometric scale of 1∶80. This research investigates the aerodynamic and aerostatic effects of upper central vertical stabilizers (UCVSs), lower central vertical stabilizers (LCVSs), horizontal stabilizers (HSs), and their combinations on two wide single box girders with an aspect ratio exceeding 12 at various angles of attack (AOAs). Wind tunnel tests optimize stabilizer layouts to improve flutter performance. For VIV, extensive wind tunnel experiments are conducted on a sectional model with a large geometric scale ratio of 1∶30. The experimental results investigate the VIV behavior of parallel twin box girders with different slot width ratios. The experiments consider wind angles of attack of ±3° and 0°, identifying 3° as the most unfavorable angle of attack. Results: The flutter tests highlighted the high sensitivity of the critical flutter wind speed to AOAs, with lower critical flutter wind speeds observed at AOAs of 1° and 2°. The application of UCVS was advantageous for increasing the critical flutter speed at positive angles of attack, whereas the utilization of LCVS was effective for the enhancement of the critical flutter speed at negative angles of attack. The combined use of central and horizontal vertical stabilizers effectively increased the critical flutter wind speed of wide single-box girders. The VIV experiments revealed significant aerodynamic interference among parallel twin box girders with different slot width ratios, notably at 3° of attack. The combination of wind fairings/winglets and skirt plates effectively suppressed VIV in parallel twin box steel girders, whereas a single aerodynamic countermeasure was insufficient. Conclusions: The comprehensive application of aerodynamic and mechanical control measures has significant potential for improving the operational stability of the Shenzhen-Zhongshan Link bridges throughout their lifecycle. Aerodynamic stabilizers effectively increased the critical flutter wind speed, whereas the combination of wind fairings and skirt plates suppressed VIV. Mechanical measures, including multiple tuned mass dampers (MTMDs), prove effective regardless of the girder's cross-section shape and wind environment. By considering mode coupling between VIV mode and non-VIV modes caused by MTMDs, optimal MTMD parameters can be designed for improved control performance. Implementing comprehensive wind-resistant designs and corresponding control measures across several bridge sections of the Shenzhen-Zhongshan Link has significant potential for improving the operational stability of bridges over their entire life cycle.